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Target intelligence / Profile preview
AMPA/Kainate Glutamate Receptor (AMPA/Kainate Receptor)
- Target
- AMPA/Kainate Receptor
- Molecular classification
- Receptor, Ion channel, Ligand-gated ion channel, Glutamate receptor
01
Overview
AMPA and kainate receptors are subtypes of ionotropic glutamate receptors that mediate fast excitatory synaptic transmission in the central nervous system. They are tetrameric complexes composed of various GluA and GluK subunits, respectively. Activation by glutamate leads to ion channel opening and neuronal depolarization, playing crucial roles in synaptic plasticity, learning, and memory. Their function is also shaped by auxiliary proteins and neuromodulators. Selective targeting of these receptors is being explored for treating various neurological and psychiatric disorders.
- Other names
- AMPA ReceptorKainate ReceptorIonotropic Glutamate Receptor (iGluR)GluR1-4 (AMPA)GluK1-5 (Kainate)Glutamate-gated ion channel
02
Mechanism of action
Ligand-gated ion channel activation leading to Na+ and/or Ca2+ influx and neuronal depolarization.
03
Biological functions
NeurotransmissionSynaptic plasticityExcitatory neurotransmissionLearningMemorySensory processingModulation of neuronal firing
04
Disease associations
Neurodegenerative diseaseEpilepsyStrokeTraumatic brain injurySchizophreniaAnxiety disordersDepressionPain
05
Safety considerations
ExcitotoxicitySeizuresNeurodegenerationOff-target effects of drugs
06
Interacting drugs
AMPA receptor agonists
7 more in the full profile.
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