Islet cell autoantigen 1, 69kDa pseudogene (null)

The "Islet cell autoantigen 1, 69kDa pseudogene" designates a *pseudogene* (nonfunctional genomic DNA sequence resembling a gene) related to *ICA1*, which encodes the protein ICA69, a known islet autoantigen in type 1 diabetes. The pseudogene itself does not produce a functional protein and therefore is not a therapeutic target, nor does it possess direct biological function or disease association. It lacks the properties of typical drug targets like receptors, enzymes, or transporters[1]. In clinical and experimental literature, *ICA69* is discussed for its role in autoimmunity, particularly type 1 diabetes[3][7], but *the pseudogene* (as identified by ENSG00000260395) is not functionally involved. If your interest is in the protein with autoimmune relevance, search for *Islet cell autoantigen 1, 69kDa* (ICA1), not the pseudogene[1][3][7]. Notes on correctness and interpretation: - *Is this a therapeutic target?* No. The pseudogene has no known function or role as a drug target. - *Is something wrong with this target?* Yes. This is a pseudogene, not an active gene or target protein. If drug discovery or functional studies are intended, the proper target is ICA1 (Islet cell autoantigen 1, 69kDa), not its pseudogene. - *Aliases:* The names found in public databases may include LOC100420536, which strictly refers to the pseudogene. - *If searching for target biology, functional studies, or druggability, ICD69/ICA1 is the correct functional gene/protein.*

Other names

ICA1 pseudogeneICA69 pseudogeneLOC100420536

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