Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (IDH3B)

Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (IDH3B) is a structural, non-catalytic subunit of the mitochondrial NAD+-dependent isocitrate dehydrogenase 3 (IDH3) enzyme complex. IDH3 catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate within the tricarboxylic acid (TCA) cycle, a key energy-generating process of glucose metabolism in mitochondria. The IDH3 complex is a heterotetramer comprised of two alpha (IDH3A), one beta (IDH3B), and one gamma (IDH3G) subunit. While the alpha subunit is responsible for enzymatic catalysis, the beta subunit (IDH3B) supports the structural assembly and stability of the complex, facilitating full enzymatic activity and optimal response to allosteric regulators. Mutations in IDH3B are linked to autosomal recessive retinitis pigmentosa (RP46), demonstrating its important physiological role. No drugs are currently reported to target this protein or its function.

Other names

Isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit betaIsocitrate dehydrogenase [NAD] subunit beta, mitochondrialIDH3BRP46NAD(+)-specific ICDH subunit betaIsocitric dehydrogenase subunit betaIsocitrate dehydrogenase (NAD(+)) 3 betaIsocitrate dehydrogenase 3 (NAD(+)) betaIsocitrate dehydrogenase 3 (NAD+) beta

Not applicable; IDH3B is not currently a pharmacological target, so drug mechanisms of action are not described in literature.