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JHDM1D antisense RNA 1 (head to head) (JHDM1D-AS1)
- Target
- JHDM1D-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense transcript, Other
01
Overview
The KDM7A divergent transcript (KDM7A-DT, also known as JHDM1D-AS1) is a long non-coding RNA transcribed from the antisense strand near the KDM7A gene locus. Unlike the protein-coding KDM7A (a histone demethylase involved in epigenetic regulation), KDM7A-DT acts at the RNA level and may function as a scaffold or guide for chromatin-modifying complexes[4]. Overexpression of KDM7A-DT in fibroblast cells has been shown to induce genotoxic stress, reduce cell proliferation, and alter gene expression profiles associated with stress response and tumorigenesis[7][6]. Its expression correlates with certain cancer subtypes and may serve as a biomarker, particularly in urothelial tumors when analyzed together with JHDM1D/KDM7A expression[5]. However, it is not currently considered a druggable therapeutic target, nor are there drugs known to directly modulate its function.
- Other names
- KDM7A divergent transcriptKDM7A-DTJHDM1D antisense RNA 1 (head to head)JHDM1D-AS1
02
Biological functions
Regulation of gene expression (including chromatin modification and potential RNA scaffold/guidance)Possible modulation of cellular stress pathways and cell cycle progressionInvolvement in cancer cell proliferation and tumorigenesis
03
Disease associations
Cancer (notably, shown to be associated with urothelial tumors and possibly gastric cancer)Other (potential role in stress response pathways)
04
Biomarkers
Expression of KDM7A-DT together with the JHDM1D/KDM7A gene may have prognostic value in urothelial tumors
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