Jumonji and AT-rich interaction domain-containing protein 2, divergent transcript (ΔN-JARID2) (JARID2-DT or ΔN-JARID2)

ΔN-JARID2 (JARID2 divergent transcript) is a truncated isoform of JARID2 lacking its N-terminal PRC2-interacting domain. In certain lineage-committed cells, such as human keratinocytes, this variant predominates and cannot bind EZH2 or stimulate PRC2 activity, unlike the full-length protein. The ΔN-JARID2 isoform opposes Polycomb repression and is critical for activating differentiation genes. It acts as an epigenetic modulator, shifting the balance from gene repression to gene activation during cell differentiation. This isoform arises from post-translational cleavage or alternative splicing and is not recognized as a canonical drug target or receptor.

Other names

ΔN-JARID2JARID2 truncated isoformJARID2 low molecular weight formJARID2-C-terminal fragment

Not applicable; no drugs targeting this isoform. For full-length JARID2 and PRC2, mechanisms include inhibition of H3K27 methylation and disruption of chromatin repression