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Target intelligence / Profile preview
K(lysine) acetyltransferase 6B (KAT6B)
- Target
- KAT6B
- Molecular classification
- Enzyme, Histone modification, Lysine acetyltransferase, MYST family
01
Overview
KAT6B is a histone acetyltransferase enzyme that plays a critical role in regulating gene expression by acetylating lysine residues on histone H3. This modification influences chromatin structure and impacts various cellular processes, including development, cell cycle progression, and DNA repair. It is implicated in developmental disorders and cancer, acting as both an oncogene and tumor suppressor depending on the cellular context, and is considered a potential therapeutic target.
- Other names
- MYST4MOZ2MORF
02
Mechanism of action
Histone acetylation, affecting gene expression
03
Biological functions
Gene transcription regulationChromatin remodelingDNA repairCell cycle progressionCell differentiationDevelopmentNeurogenesisSkeletal formationEpigenetic regulation
04
Disease associations
Genitopatellar syndromeYoung–Simpson syndromeAcute myeloid leukemiaCancerIntellectual disability
05
Safety considerations
Potential for off-target effects due to broad tissue distributionContext-dependent role as oncogene or tumor suppressor
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