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KBTBD11 overlapping transcript 1 (KBTBD11-OT1) is a long non-coding RNA gene located on chromosome 8 (GRCh38: 1,966,872–1,992,616 forward strand)[2]. It is annotated in genome databases as a non-coding RNA and does not code for a protein. KBTBD11-OT1 is transcriptionally distinct from KBTBD11, a well-studied protein-coding gene with functional roles in tumorigenesis, fat metabolism, and bone biology. However, there is currently no detailed functional, mechanistic, or therapeutic information about KBTBD11-OT1 itself in the scientific literature or curated gene databases. Any inferred molecular or disease associations based on the KBTBD11 locus refer to the protein-coding gene, not this lncRNA transcript[2]. If you intended to inquire about the protein-coding gene KBTBD11, please specify, as this would have extensive roles in cell signaling, cancer, obesity, and bone remodeling[1][3]. For KBTBD11-OT1, information is currently limited to non-protein-coding RNA gene annotations without designated therapeutic or biomarker status[2].
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