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Keratin, type I cuticular Ha1 (KRT31)
- Target
- KRT31
- Molecular classification
- Intermediate filament protein, Structural protein, Keratin (type I, acidic)
01
Overview
Keratin, type I cuticular Ha1 (KRT31), is an acidic intermediate filament protein predominately expressed in hair follicles and nails. It is essential for the structural integrity and mechanical strength of hair, forming heterodimers with type II keratins in the hair cortex. KRT31 is clustered with other type I hair keratins on chromosome 17 and is critical for ectodermal appendage formation. Loss or mutation of KRT31 impairs hair strength and is associated with genetic conditions such as monilethrix, a congenital hair disorder, and it may serve as a biomarker for epithelial differentiation in contexts like oral dysplasia. While commercially utilized in cosmetic products for hair repair, KRT31 itself is not considered a classic therapeutic target such as a receptor or enzyme[1][2][3][4][5].
- Other names
- HA1HHA1KRTHA1HKA1K31Ha-1Hair keratin, type I Ha1Keratin-31hard keratin type I 1hHa1hard keratin, type I, 1keratin 31, type Ikeratin, hair, acidic
02
Biological functions
Structural component of hair and nailsFormation and integrity of ectodermal appendagesHeterodimerization with type II keratinsCritical for tensile strength, elasticity, and mechanical support of hair
03
Disease associations
Monilethrix (rare congenital hair disorder)Abnormal hair/nail differentiationOral epithelial dysplasia (biomarker role)Other hair shaft disorders
04
Biomarkers
Altered expression in dysplastic oral leukoplakia (potential early marker for aberrant epithelial cell differentiation)
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