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Keratin, type I cuticular Ha3-I (KRT33A)

Target: KRT33A
Molecular classification: Intermediate filament protein, Type I (acidic) keratin, Cytoskeletal protein

Overview

Keratin, type I cuticular Ha3-I (KRT33A) is a member of the keratin gene family and encodes a type I (acidic) hair keratin protein[1]. It is primarily expressed in hair and nails, where it heterodimerizes with type II keratins to form structural intermediate filaments critical for the formation and mechanical properties of hair and nail[1]. This gene is clustered with other type I hair keratin genes on human chromosome 17q21.2 and is distinct from its closely related isoform, KRT33B, by being encoded by a separate gene[1]. The main biological role of KRT33A is its contribution to the structural integrity of hair fibers; no evidence currently exists for its direct role as a therapeutic target, disease biomarker, or drug interaction.

Other names: Keratin 33AKRT33AKeratin, type I cuticular Ha3-IHHA3-IHKA3AKRTHA3AK33AHa-3IKrt1-3Hair keratin, type I Ha3-IKeratin-33Ahard keratin type I 3IHA3IhHa3-Ihard keratin, type I,3Ikeratin 33A, type Ikeratin, hair, acidic, 3A

Biological functions

Structural support in hair and nailHeterodimerization with type II keratins for hair and nail formation

Disease associations

Other (insufficient direct evidence for involvement in major disease categories)

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