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Target intelligence / Profile preview
Keratin, type I cuticular Ha8 (KRT38)
- Target
- KRT38
- Molecular classification
- Cytoskeletal protein, Type I keratin, Intermediate filament protein
01
Overview
Keratin, type I cuticular Ha8 (KRT38) is a member of the keratin gene family coding for a type I acidic keratin protein. It is asymmetrically distributed in human hair follicles and forms heterodimers with type II keratins, contributing to intermediate filament (IF) assembly in hair and the cytoskeleton of epithelial cells. KRT38 does not have orthologs in mice or horses and is not directly implicated in human disease or targeted by drugs[1][3]. It primarily provides structural integrity and resilience to hair fibers and is not considered a receptor, enzyme, or transporter. Its main function is mechanical, supporting hair morphology[1][2].
- Other names
- KRT38HA8KRTHA8hHa8keratin 38HKA8K38Hair keratin, type I Ha8Keratin-38keratin, type I cuticular Ha8keratin 38, type Ikeratin, hair, acidic, 8
02
Mechanism of action
Not applicable; no drugs known to target this protein
03
Biological functions
Structural component of hairMaintenance of hair follicle integrityContributes to epithelial cell mechanical stability
04
Disease associations
Other (No direct evidence of involvement in cancer, inflammation, neurodegenerative, cardiovascular, or infectious diseases)
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