Keratin, type I cytoskeletal 24 (KRT24)

Keratin 24 (KRT24) is a type I intermediate filament protein expressed predominantly in differentiated epithelial tissues, especially the suprabasal layer of the corneal epithelium, with lower levels in epidermis and other squamous epithelia[3]. It plays a role in keratinocyte terminal differentiation, inhibition of cell cycle progression at G1/S, induction of senescence, autophagy, and apoptosis, and suppression of cell migration, possibly through PKCδ signaling[1]. KRT24 is not essential for cytoskeletal formation, but it likely contributes to the specialized properties of differentiated epithelial cells. It may serve as a marker of aging, differentiation, and has potential as a biomarker for certain skin and corneal conditions, but is not recognized as a therapeutic target or receptor at present[1][3].

Other names

Cytokeratin-24CK-24KA24K24MGC138169MGC138173FLJ20261Keratin-24Type I keratin-24Keratin 24KRT24

Not applicable, as there are no known drugs targeting KRT24. Mechanistic studies show it functions through the PKCδ signaling pathway affecting cell cycle arrest, apoptosis, and differentiation[1].