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Keratin, type I cytoskeletal 25 (KRT25)
- Target
- KRT25
- Molecular classification
- Intermediate filament protein, Type I keratin, Cytoskeletal protein
01
Overview
Keratin, type I cytoskeletal 25 is a structural protein encoded by the KRT25 gene, located on human chromosome 17q21.2, and classified as a type I keratin within the family of intermediate filament proteins[3][8]. It is essential for the proper assembly of type I and type II keratin complexes and the formation of robust keratin intermediate filaments specifically in the inner root sheath of hair follicles[4][1][7]. Mutations or disruptions in KRT25 are known to cause hair abnormalities such as fragile, curly hair in humans and mice[8]. KRT25 does not function as a receptor, enzyme, or drug target, but rather as a vital structural protein for maintaining hair follicle integrity.
- Other names
- Keratin 25KRT25Keratin-25Cytokeratin-25CK-25K25K25AKeratin-25AKeratin, type I cytoskeletal 25Type I inner root sheath-specific keratin-K25irs1ARWH3KRT24IRS1
02
Mechanism of action
Not applicable
03
Biological functions
Cytoskeletal structural supportAssembly of keratin intermediate filaments in the inner root sheath of hair follicleHair follicle differentiation and stability
04
Disease associations
Human hair abnormality (mutations in KRT25 cause fragile, curled hair)Other (no strong links to cancer or major systemic diseases)
05
Safety considerations
Not applicable
06
Interacting drugs
None known
07
Biomarkers
Changes in KRT25 expression (mutation or dysregulation) may serve as a biomarker for hair shaft dysplasia or certain hair disorders, though this is not commonly used clinically
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