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Keratin, type I cytoskeletal 40 (KRT40)
- Target
- KRT40
- Molecular classification
- Intermediate filament protein, Type I (acidic) keratin, Structural protein
01
Overview
Keratin, type I cytoskeletal 40 (KRT40) is a member of the acidic type I keratin family and forms part of the intermediate filament network in epithelial cells, contributing to the cytoskeletal structure alongside actin and microtubules. It is encoded on chromosome 17q12-q21 and is mainly involved in structural support, cellular integrity, and epithelial cell differentiation. KRT40 may play a specific role in late hair differentiation. Mutations or dysfunction have been associated with certain skin disorders such as steatocystoma multiplex and with heart fibrosarcoma, but it is not a classical drug target such as a receptor, enzyme, or transporter.
- Other names
- Keratin 40KA36CK-40K40FLJ36600Cytokeratin-40Type I hair keratin Ka36keratin, type I cytoskeletal 40cytokeratin-40type I hair keratin KA36
02
Biological functions
Structural molecule activity (component of cytoskeleton)Epithelial cell differentiationIntermediate filament organizationPossibly involved in late hair differentiation
03
Disease associations
Heart fibrosarcomaSteatocystoma multiplex
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