Keratin, type II cytoskeletal 1 (KRT1)

Keratin, type II cytoskeletal 1 (KRT1), is a **major type II intermediate filament protein** expressed predominantly in the suprabasal layers of the epidermis, where it forms heterodimers with keratin 10 or keratin 9 to create the intermediate filament cytoskeleton essential for skin integrity and barrier function[1][2][3][5]. KRT1 provides mechanical strength and resilience to keratinocytes, protecting skin against physical stress. Pathogenic variants in KRT1 disrupt the intermediate filament network, causing skin fragility and leading to disorders such as **epidermolytic hyperkeratosis**, characterized by blistering and thickened skin[1][2][3]. Beyond structural roles, KRT1 also contributes to the regulation of keratinocyte differentiation and inflammatory responses in the epidermis[5]. There are currently no drugs that directly target KRT1, and modulation could pose risks to skin integrity.

Other names

Keratin 1KRT1KRTACK-1K1KRT1A67 kDa cytokeratinCytokeratin-1Hair alpha proteinType-II keratin Kb1AEI2CK1EHKEHK1EPPKNEPPKcytokeratin 1epidermolytic hyperkeratosis 1

Not applicable (no known direct therapeutic targeting)