Keratin, type II cytoskeletal 3 (KRT3)

Keratin, type II cytoskeletal 3 (KRT3) is a structural protein that belongs to the type II (basic) cytokeratin family and forms intermediate filaments together with keratin 12 in the corneal epithelium. It plays a critical role in providing resilience and mechanical stability to the outermost layer of the cornea, protecting the eye against mechanical and microbial insults. KRT3 expression is specific to differentiated corneal epithelial cells and is regulated by transcription factors important for ocular surface development. Mutations in the KRT3 gene are causative for Meesmann corneal dystrophy, a disorder characterized by intraepithelial microcyst formation and corneal fragility, but KRT3 itself is not a therapeutic target for drugs[1][2][3][4][5][6].

Other names

Keratin 3CK-3CK3K3Cytokeratin 3Cytokeratin-3Type-II keratin Kb3K2C3_HUMAN65 kDa cytokeratinKeratin 3, type IIKeratin, type II cytoskeletal 3

Not applicable (structural protein, not a common drug target)