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Target intelligence / Profile preview
Keratin, type II cytoskeletal 7 (CK7)
- Target
- CK7
- Molecular classification
- Intermediate filament protein, Cytoskeletal protein, Type II keratin, Structural protein
01
Overview
Keratin, type II cytoskeletal 7 is a structural protein encoded by the KRT7 gene in humans. It is a type II (basic/neutral) keratin predominantly expressed in simple epithelial linings of internal organ cavities, gland ducts, and blood vessels. Keratin-7 forms heterodimers with type I keratins (such as keratin-19), contributing to the cytoskeletal structure and mechanical integrity of epithelial cells. It plays critical roles in cell adhesion, migration, and signaling, and serves as an important immunohistochemical marker for the identification and differentiation of certain carcinomas, including ovarian and transitional cell carcinomas. Keratin-7 is not considered a direct drug target but is widely utilized in diagnostic pathology to assess tissue origin of tumors
- Other names
- Cytokeratin-7CK-7Keratin-7Sarcolectin (SCL)Type-II keratin Kb7K7
02
Biological functions
Structural constituent of epidermisIntermediate filament organizationCellular adhesionCellular migrationCellular signalingBlocks interferon-dependent interphaseStimulates DNA synthesis in cellsTranslational regulation (HPV16 E7 mRNA)
03
Disease associations
Cancer (especially as a diagnostic marker for carcinomas, e.g., ovarian and transitional cell carcinomas)Other (used in differential diagnosis of tissue origin in tumors)
04
Biomarkers
Commonly used as a biomarker in immunohistochemistry for distinguishing between carcinomas (e.g., ovarian, transitional cell) and others like colonic and prostate cancer
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