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Keratin, type II cytoskeletal 71 (KRT71)
- Target
- KRT71
- Molecular classification
- Other (Intermediate filament protein, Keratin, Structural protein)
01
Overview
Keratin, type II cytoskeletal 71 (KRT71) is an intermediate filament protein primarily expressed in the inner root sheath of the hair follicle, where it plays a central role in hair formation by contributing to the structural framework that supports hair fiber development and maintenance. Mutations in this gene have been associated with hair disorders such as Hypotrichosis 13 and Familial woolly hair syndrome[1][2][3][4][5][6]. KRT71 belongs to the family of type II keratins, clustered on chromosome 12, and is not classified as a traditional therapeutic target, receptor, or enzyme.
- Other names
- Keratin 71K6IRS1KB34KRT6IRS1CK-71K71Keratin 6 irshK6irshK6irs1KRT6IRSCytokeratin-71Keratin-71Type II inner root sheath-specific keratin-K6irs1Type-II keratin Kb34HYPT13keratin, type II cytoskeletal 71cytokeratin-71type II inner root sheath-specific keratin-K6irs1type-II keratin Kb34
02
Biological functions
Structural integrity of epithelial cellsHair formationComponent of intermediate filaments in the inner root sheath of hair follicle
03
Disease associations
Hair disorders (e.g., Hypotrichosis 13, Familial woolly hair syndrome)[2]
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