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Keratin, type II cytoskeletal 75 (KRT75)
- Target
- KRT75
- Molecular classification
- Structural protein, Type II keratin family, Intermediate filament protein
01
Overview
Keratin, type II cytoskeletal 75 (KRT75) is a structural protein and a member of the type II keratin family, located on the long arm of chromosome 12[1][2]. It is a critical component of keratin intermediate filaments, primarily expressed in the companion layer of the hair follicle, where it is essential for the formation and structural integrity of hair and nails[1][2][4]. Mutations in KRT75 are associated with various hair and nail disorders, including loose anagen syndrome and pseudofolliculitis barbae, and its dysfunction can also play a role in certain cancers[1][2].
- Other names
- CK-75K6HFK75KB18PFBhK6hfCytokeratin-75Keratin-6 hair follicleType II keratin-K6hfType-II keratin Kb18
02
Biological functions
Structural integrity of hair and nailsComponent of keratin intermediate filaments in the companion layer of the hair follicle
03
Disease associations
Hair and nail disorders (e.g., loose anagen syndrome, pseudofolliculitis barbae, uncombable hair syndrome, autosomal dominant wooly hair, Marie Unna hereditary hypotrichosis, monilethrix, hypotrichosis simplex, ringed hair disease, epidermolytic palmoplantar keratoderma, nonsyndromic congenital nail disorder 3)Cancer (e.g., esophageal cancer, low grade glioma)
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