Target intelligence / Profile preview

Keratin (Stratum Corneum) (N/A)

Target: N/A
Molecular classification: Intermediate Filament Protein, Structural Protein

Overview

Keratin is a structural, fibrous protein that forms the primary component of corneocytes in the stratum corneum. It provides mechanical strength, prevents water loss, contributes to skin elasticity, and protects against environmental insults. Alterations in keratin structure or function can lead to various skin disorders, making it a key target for dermatological research and therapy.

Other names: Epidermal KeratinStratum Corneum KeratinCorneocyte Keratin

Mechanism of action

N/A

Biological functions

Mechanical StrengthWater RetentionBarrier ProtectionSkin ElasticityCornification

Disease associations

IchthyosisEczemaBlistering ConditionsDry SkinScaling Disorders

Safety considerations

Potential for allergic reactions or irritations with topical applicationsTargeting specific keratin isoforms for therapeutic intervention can be challenging due to heterogeneity

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