Keratin (stratum corneum type)

Keratin in the stratum corneum refers to a family of structural proteins that form intermediate filaments within terminally differentiated epidermal cells called corneocytes. These proteins are the major non-aqueous component of the outermost layer of human skin—the stratum corneum—and play an essential role in maintaining hydration by retaining water within cells and providing mechanical strength to resist abrasion[1][3][4]. The organization of these filaments follows specialized packing models that contribute to both flexibility and toughness. While critical for healthy barrier function, "stratum corneum keratin" is not considered an individual druggable therapeutic target such as an enzyme or receptor; rather, it represents a class of structural proteins integral to normal epidermal physiology[5]. The term itself is somewhat imprecise because multiple types/subtypes of keratins exist throughout different layers and cell types within the epidermis. The entry "Stratum corneum keratin" does not refer to a single defined molecular entity or recognized drug target but rather describes structural proteins present in the outermost layer of skin. For structured data purposes, this should be flagged as incorrect if seeking canonical therapeutic targets like receptors or enzymes.

Other names

Stratum corneum keratinEpidermal keratin (in the context of the stratum corneum)Corneocyte keratin