Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Keratin 19, also known as Cytokeratin 19 (CK-19) (CK-19)
- Target
- CK-19
- Molecular classification
- Intermediate filament protein, Cytokeratin
01
Overview
Keratin 19 is a type I cytokeratin, a cytoplasmic intermediate filament protein, playing a crucial role in maintaining the structural integrity of epithelial cells. It is often used as a biomarker for detecting tumor cells, particularly in cancers like breast, lung, and stomach carcinomas. CK-19 is also involved in cancer stem cell reprogramming and modulating drug sensitivity in cancer cells.
- Other names
- Keratin, type I cytoskeletal 19K1C19KRT19
02
Mechanism of action
Not applicable as it is primarily used as a biomarker rather than a therapeutic target.
03
Biological functions
Structural integrity of epithelial cellscell cycle regulationcancer stem cell reprogrammingdrug sensitivity modulation
04
Disease associations
Cancer, particularly carcinomas of the lung, breast, stomach, pancreas, ovaryeccrine porocarcinomafollicular adenoma
05
Safety considerations
False positivity in RT-PCR studies can occur due to illegitimate transcription, pseudogenes, sample contamination, and other factors.
06
Biomarkers
CYFRA 21-1, a soluble fragment of KRT19, is used as a tumor marker.
Beyond the preview
Go deeper on Keratin 19, also known as Cytokeratin 19 (CK-19) (CK-19).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Keratin 19, also known as Cytokeratin 19 (CK-19) (CK-19).