Keratin 43, pseudogene (KRT43P)

Keratin 43, pseudogene (KRT43P) is a non-functional, pseudogenized member of the keratin gene family, which consists of intermediate filament proteins and keratin-associated proteins (KAPs) involved in the structural integrity of hair, skin, and epithelia in mammals[1][2][3]. Pseudogenes are gene sequences that have lost their protein-coding potential due to disruptive mutations and are not transcribed into functional proteins[1][2]. “KRT43P” appears to be a misapplied name, as it does not conform to standard keratin or keratin-associated protein nomenclature, and is not recognized as a protein-coding gene nor as a therapeutic or diagnostic target; it likely refers to a predicted or hypothetical gene classified as a non-functional relic, not a molecular target in disease or drug discovery. Notes on correctness and target status: - The standard human keratin gene system does not include a “KRT43” functional gene; “KRTAP” designations are for keratin-associated proteins, and the “p” suffix denotes a pseudogene[2][1]. The entity described as “KRT43P” is strictly a pseudogene, not a druggable or biologically functional entity, and is not considered a classical molecular target[1][2]. - There is no evidence for disease association, biological function, or therapeutic relevance for “KRT43P”; it is not referenced in genetic, proteomic, or clinical drug databases as a target. - If the query refers specifically to the canonical keratin family, valid targets would be properly named proteins like “Keratin, type I cytoskeletal 10 (KRT10)” or similar[3]. The current entry is non-canonical and non-actionable. Summary: - Keratin 43, pseudogene (KRT43P) is a non-functional gene remnant, not a molecular target, with no biological role, disease association, or therapeutic relevance[1][2]. - The abbreviation and name do not correspond to an actionable or canonical gene, making this entry incorrect as a molecular target.

Other names

Keratin-associated protein 43, pseudogeneKRTAP43P