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KH domain-containing, RNA-binding, signal transduction-associated protein 2 (KHDRBS2)
- Target
- KHDRBS2
- Molecular classification
- Other (RNA-binding protein), Splicing factor
01
Overview
KH domain-containing, RNA-binding, signal transduction-associated protein 2 (KHDRBS2) is a nuclear protein involved in the regulation of alternative pre-mRNA splicing, affecting splice site selection and exon inclusion by binding to poly(A) and poly(U) RNA sequences. Its activity is modulated by phosphorylation, which can inhibit its RNA-binding function. KHDRBS2 acts synergistically or antagonistically with related splicing factors such as SAM68 and may serve as an adapter protein for Src kinases in mitosis. Clinically, the gene has roles in specific types of renal cell carcinoma, but currently has no established role as a direct therapeutic target[1][2][5][6].
- Other names
- SLM1SLM-1Sam68-like mammalian protein 1KHDRBS2 3'UTR overlapping transcript 1KHDRBS2-OT1KHDRBS2-OTKH RNA binding domain containing, signal transduction associated 2mSLM-1RP1-240B8.3Slim1
02
Biological functions
Alternative splicing regulationmRNA bindingPoly(A) bindingSignal transduction adapter
03
Disease associations
Cancer (TFEB-rearranged renal cell carcinoma)Renal cell carcinoma with MiT translocations
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