KH domain containing 4, pre-mRNA splicing factor (KHDC4)

KH domain containing 4, pre-mRNA splicing factor (KHDC4) is an RNA-binding protein involved in the splicing of pre-mRNA, particularly through roles in mRNA splice site recognition and regulation of splice site selection[4][5][7]. It is a predicted component of the spliceosomal complex, interacts with the PRP19C/NTC/Nineteen complex, and binds to RNAs with A/C-rich sequences and poly-C stretches[2][4][7]. KHDC4 is predominantly localized to the nucleus and spliceosomes[1][4][7]. Diseases associated with mutations or dysregulation of KHDC4 include lip cancer[4]. There are no current known drugs or approved modulators that specifically target this protein or receptor, nor are there established biomarkers or known safety concerns associated with therapeutic targeting of KHDC4[4][5][7]. The function of KHDC4 is not yet fully elucidated, though it is implicated broadly in RNA metabolism and splicing regulation[2][4].

Other names

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