Kidney yin deficiency pattern (KYDS) (KYDS)

Kidney yin deficiency pattern is a fundamental clinical syndrome in Traditional Chinese Medicine (TCM) representing a state of diminished cooling and moistening functions within the body's regulatory systems (WHO, 2007). It is characterized by symptoms such as night sweats, low-grade fever, dizziness, and soreness of the lower back and knees. From a modern biomedical perspective, this pattern is not a single molecular target but a complex physiological state often associated with dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and endocrine imbalances (PubMed: PMC3134625). It is frequently linked to altered immune function and oxidative stress in aging and chronic diseases like diabetes and hypertension.\n\nTreatment typically involves multi-component herbal formulas, such as Liuwei Dihuang Wan, which act on various pathways to restore internal balance rather than binding to a single receptor. Research suggests that these interventions may modulate immune responses and metabolic pathways across multiple organ systems (Zhao et al., 2011). Because it is a systemic pattern rather than a single protein, it does not fit the traditional one drug, one target model of pharmacology. Instead, it represents a systems-biology challenge where therapeutic efficacy is measured by the restoration of homeostatic equilibrium. Understanding this pattern requires integrating TCM diagnostic criteria with modern biomarkers like cortisol and cyclic nucleotide ratios.

Other names

Kidney Yin Deficiency SyndromeShen-Yin-XuRenal Yin DeficiencyKidney Yin Vacuity

Restoration of systemic homeostasis through multi-target herbal constituents that modulate the HPA axis and immune-endocrine-metabolic network (Pharmacopoeia of the PRC, 2020).