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Target intelligence / Profile preview
KIT Proto-Oncogene, Receptor Tyrosine Kinase (c-KIT)
- Target
- c-KIT
- Molecular classification
- Receptor Tyrosine Kinase, Type III Receptor Tyrosine Kinase
01
Overview
c-KIT, also known as CD117 or stem cell factor receptor (SCFR), is a type III receptor tyrosine kinase that plays a crucial role in regulating cell proliferation, survival, migration, and differentiation. Dysregulation through overexpression or mutations can lead to oncogenic transformation, promoting tumorigenesis in several cancers. Targeting mutant or overactive c-KIT with small molecule inhibitors has become an important therapeutic strategy.
- Other names
- CD117SCFRMast/stem cell growth factor receptor
02
Mechanism of action
Small molecule inhibitors targeting the tyrosine kinase activity of c-KIT
03
Biological functions
Cell proliferationCell survivalCell differentiationCell migrationHematopoiesisMelanogenesisGametogenesisGastrointestinal motilitySignal transduction
04
Disease associations
Gastrointestinal Stromal Tumors (GISTs)Acute Myeloid Leukemia (AML)MastocytosisMelanomaBreast CancerThyroid CancerColorectal CancerCancer
05
Safety considerations
Drug resistanceOff-target effectsToxicity
06
Interacting drugs
07
Biomarkers
c-KIT expressionKIT mutations
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