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Klebsiella pneumoniae Genome (CRISPR-Cas3 Target) (K. pneumoniae Genome)
- Target
- K. pneumoniae Genome
- Molecular classification
- Genome, DNA, Bacterial Genome
01
Overview
The Klebsiella pneumoniae genome, comprising both chromosomal and plasmid DNA, serves as the target for CRISPR-Cas3 based antimicrobial strategies. The system utilizes guide RNAs to direct the Cascade complex to specific regions within the genome, leading to the recruitment of Cas3, which then degrades the DNA in an ATP-dependent manner. This approach aims to eradicate resistant strains by causing large deletions in essential genes or antibiotic resistance loci. Efficient delivery of the CRISPR-Cas3 components into bacterial cells remains a major challenge.
- Other names
- K. pneumoniae ChromosomeK. pneumoniae PlasmidsKlebsiella pneumoniae DNAK. pneumoniae Genetic Material
02
Mechanism of action
CRISPR-Cas3 mediated DNA degradation via Cascade complex recognition of target DNA and subsequent Cas3-mediated unwinding and degradation.
03
Biological functions
Genetic Information StorageProtein SynthesisReplicationTranscription
04
Disease associations
InfectionAntibiotic ResistanceVirulence
05
Safety considerations
Off-target effects of CRISPR-Cas3 systemDelivery challenges of CRISPR-Cas3 componentsDevelopment of resistance to CRISPR-Cas3 therapyPotential for unintended consequences due to widespread genomic degradation
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