Kruppel-like factor 5 messenger RNA 3' untranslated region (KLF5 mRNA 3′UTR)

The Kruppel-like factor 5 (KLF5) mRNA 3' untranslated region (3'UTR) is a critical regulatory segment of the KLF5 transcript that governs its stability and translation efficiency (NIH, 2021). KLF5 is a zinc-finger transcription factor that plays a pivotal role in cell proliferation, differentiation, and the maintenance of stemness, particularly in the intestinal epithelium and vascular smooth muscle cells (NIH, 2021; NIH, 2015). The 3'UTR contains multiple binding sites for microRNAs (miRNAs) and RNA-binding proteins, making it a focal point for post-transcriptional gene regulation (NIH, 2021; D-NB, 2022). In various cancers, such as colorectal and pancreatic cancer, dysregulation of the KLF5 3'UTR-mediated control leads to KLF5 overexpression, which promotes tumor growth, metastasis, and chemoresistance (NIH, 2019; NIH, 2021). Consequently, the KLF5 mRNA 3'UTR is an emerging therapeutic target for RNA-based interventions, including miRNA mimics and antisense oligonucleotides, aimed at silencing KLF5 expression to inhibit oncogenic signaling and restore drug sensitivity (NIH, 2015; NIH, 2021). Experimental agents like miR-4711-5p mimics have demonstrated the ability to bind this region and suppress cancer stem cell properties in preclinical models (NIH, 2021).

Other names

KLF5 3'UTRBTEB2 mRNA 3'UTRIKLF mRNA 3'UTRKruppel-like factor 5 3' untranslated region

Modulation of KLF5 expression through miRNA-mediated gene silencing, RNA interference, or antisense-mediated mRNA degradation and translational inhibition.