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Target intelligence / Profile preview
L,D-Transpeptidase
- Molecular classification
- Enzyme
01
Overview
L,D-transpeptidases (LDTs) are a class of bacterial enzymes involved in the cross-linking of peptidoglycan, a critical component of the bacterial cell wall. Unlike the more common D,D-transpeptidases (penicillin-binding proteins, PBPs), which form 4-3 peptide cross-links, LDTs catalyze the formation of 3-3 cross-links between adjacent stem peptides in peptidoglycan. They are important drug targets because they confer resistance to β-lactam antibiotics. Carbapenems can inhibit some bacterial LDTs.
02
Mechanism of action
Inhibition of peptidoglycan cross-linking
03
Biological functions
Peptidoglycan cross-linkingCell wall biosynthesisBacterial cell integrity
04
Disease associations
Antibiotic resistanceInfection
05
Safety considerations
Inhibition can lead to cell lysis or reduced bacterial fitness.Resistance mechanisms can emerge to overcome inhibition.
06
Interacting drugs
Carbapenems
1 more in the full profile.
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