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L Protein (RNA-dependent RNA Polymerase) of Respiratory Syncytial Virus (L protein)
- Target
- L protein
- Molecular classification
- Enzyme, RNA-dependent RNA polymerase, Polyribonucleotidyl transferase, Methyltransferase
01
Overview
The L protein of respiratory syncytial virus (RSV) is a large, multifunctional enzyme that serves as the viral RNA-dependent RNA polymerase (RdRp). It is essential for RSV genome replication and transcription, catalyzing several enzymatic activities required for the synthesis and processing of viral RNAs. The functional polymerase complex minimally requires two proteins: L and P (phosphoprotein). The multiple catalytic activities housed within one polypeptide make L an attractive target for antiviral intervention.
- Other names
- RSV L proteinRNA-dependent RNA Polymerase of RSV
02
Mechanism of action
Inhibition of RNA-dependent RNA polymerase activity, inhibition of mRNA capping, inhibition of mRNA methylation
03
Biological functions
RNA replicationRNA transcriptionmRNA cappingmRNA methylationmRNA polyadenylation
04
Disease associations
InfectionRespiratory Syncytial Virus infection
05
Safety considerations
Resistance mutationsPotential for off-target effects due to multifunctional nature
06
Interacting drugs
RSV L polymerase inhibitors (small-molecule)
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