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Target intelligence / Profile preview
L-type Calcium Channel alpha(α)₁D Subunit
- Molecular classification
- Ion channel, Voltage-gated calcium channel, L-type calcium channel
01
Overview
Cav1.3 is an L-type voltage-gated calcium channel encoded by the CACNA1D gene. It plays a critical role in various physiological processes, including pacemaking activity in the heart, neurotransmitter release, and hormone secretion. It's characterized by a more negative activation threshold compared to other L-type channels and is a target for dihydropyridines and other calcium channel blockers. Mutations and dysregulation are linked to cardiac arrhythmias, neuropsychiatric disorders, and hearing loss. Emerging evidence suggests its involvement in certain cancers, making it a potential therapeutic target.
- Other names
- Cav1.3CACNA1DCalcium voltage-gated channel subunit alpha1 D
02
Mechanism of action
Blocks calcium influx through the channel pore, reducing intracellular calcium levels.
03
Biological functions
Pacemaking currentsNeurotransmitter releaseHormone releaseMuscle contractionRegulation of neuronal firing patternsCalcium signaling
04
Disease associations
Cardiac arrhythmiasNeuropsychiatric disordersHearing lossParkinson's diseaseCancer
05
Safety considerations
Potential cardiovascular side effects (though selective blockers aim to minimize these)Drug interactions with other antihypertensive or antiarrhythmic medications
06
Interacting drugs
Dihydropyridines
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