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L-type calcium channel subunit alpha-1C (CaV1.2) (CaV1.2)
- Target
- CaV1.2
- Molecular classification
- Ion channel, Voltage-gated calcium channel
01
Overview
L-type calcium channel subunit alpha-1C (CaV1.2) is the dominant voltage-gated calcium channel expressed in vascular smooth muscle cells and is responsible for the major influx of Ca²⁺ that triggers muscle contraction, gene expression, and cellular signaling[2][3][6]. CaV1.2 operates as a heteromeric complex and is essential for regulating vascular tone and arterial contractility; dysfunction or overactivation contributes to disorders such as hypertension and vascular complications of diabetes[2][3][6]. CaV1.2 is therapeutically targeted by calcium channel blockers (such as amlodipine and nifedipine) used in the management of hypertension and cardiovascular diseases by inhibiting channel-mediated calcium entry and thus reducing vascular smooth muscle contraction[2][3][6].
- Other names
- L-type calcium channelVoltage-gated calcium channel subunit alpha-1CCaV1.2 channelLTCCCACNA1C
02
Mechanism of action
Calcium channel blockade (prevention of Ca²⁺ influx); Inhibition of vasoconstriction/contraction
03
Biological functions
Regulation of vascular smooth muscle contractionSignal transductionControl of myogenic toneRegulation of gene expression
04
Disease associations
Cardiovascular diseaseHypertensionDiabetes (vascular complications)Vascular dysfunction
05
Safety considerations
HypotensionBradycardiaEdemaNegative inotropy in heart failure
06
Interacting drugs
Amlodipine
3 more in the full profile.
07
Biomarkers
CaV1.2 expression levels in vascular smooth muscle (experimental/research)
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