Laminin receptor 1 (LAMR1) (LAMR1)

Laminin receptor 1 (LAMR1), also known as the 37/67-kDa laminin receptor or Ribosomal Protein SA (RPSA), is a multifunctional protein that serves as a primary cell-surface receptor for Adeno-associated virus serotype 8 (AAV8) (Akache et al., 2006). While it functions intracellularly as a component of the 40S ribosomal subunit, its expression on the plasma membrane of hepatocytes is a critical determinant of the high liver tropism and transduction efficiency exhibited by AAV8-based gene therapies (UniProt P08865). AAV8 capsids bind to the extracellular domain of LAMR1 to facilitate viral attachment and subsequent internalization via receptor-mediated endocytosis (Zincarelli et al., 2008). In addition to LAMR1, the universal Adeno-associated virus receptor (AAVR, also known as KIAA0319L) is required for the post-attachment trafficking of AAV8 within the cell (Pillay et al., 2016). LAMR1's involvement in cell-matrix adhesion and its frequent overexpression in various cancers make it a significant factor in both viral vector design and oncology (Nelson et al., 2008). Understanding the interaction between AAV8 and LAMR1 is essential for optimizing liver-directed gene transfer and managing the safety profile of therapies for conditions like hemophilia and metabolic disorders (Wang et al., 2010).

Other names

37/67-kDa laminin receptorRibosomal protein SARPSALaminin-binding proteinLBPNEM/1CHD467LR37LRP

Mediates viral attachment to the hepatocyte surface and facilitates cellular entry via receptor-mediated endocytosis