Target intelligence / Profile preview

Lanosterol 14-alpha Demethylase (Fungal)

Molecular classification: Enzyme, Cytochrome P450 monooxygenase, Cytochrome P450 superfamily

Overview

Lanosterol 14-alpha demethylase, also known as CYP51, is a cytochrome P450 enzyme that plays a critical role in the biosynthesis of ergosterol, an essential component of fungal cell membranes. This enzyme catalyzes the oxidative removal of the 14α-methyl group from lanosterol through a three-step monooxygenation process. The resulting product is further processed to form ergosterol, which regulates membrane permeability and rigidity in fungi. It is the primary target for azole antifungals, and resistance can arise through amino acid substitutions or increased efflux pump activity.

Other names: Sterol 14α-demethylaseCYP51ERG11

Mechanism of action

Inhibition of lanosterol 14-alpha demethylase, leading to depletion of ergosterol and accumulation of toxic sterols.

Biological functions

Ergosterol biosynthesis

Disease associations

Infection

Safety considerations

Drug resistance due to mutations in the CYP51 gene or increased efflux pump activity.

Interacting drugs

Imidazoles

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