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Lecithin:retinol acyltransferase (LRAT)
- Target
- LRAT
- Molecular classification
- Enzyme, Acyltransferase, NlpC/P60 superfamily
01
Overview
Lecithin:retinol acyltransferase (LRAT) is a microsomal enzyme that plays a critical role in vitamin A metabolism. It catalyzes the esterification of all-trans-retinol to all-trans-retinyl esters, which are essential for vitamin A storage and visual function. LRAT is highly expressed in liver and eye tissues, particularly in the retinal pigment epithelium. Mutations or deficiencies can cause early-onset severe retinal dystrophy. Overexpression has been observed in colorectal cancer.
- Other names
- LCA14Phosphatidylcholine--retinol O-acyltransferase
02
Mechanism of action
Catalyzes the transfer of an acyl group from phosphatidylcholine to all-trans-retinol, forming all-trans-retinyl esters.
03
Biological functions
Vitamin A metabolismRetinyl ester synthesisVitamin A storageRetinoid cyclePhototransduction
04
Disease associations
Leber Congenital Amaurosis type 14Retinitis PigmentosaRetinal dystrophyColorectal cancer
05
Safety considerations
Mutations or deficiencies can cause severe retinal dystrophy.Overexpression correlates with poor prognosis in colorectal cancer.
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