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Target intelligence / Profile preview
Lewis A-like glycol-epitope (AG-7 antigen) (AG-7 antigen)
- Target
- AG-7 antigen
- Molecular classification
- Glycol-epitope, Tumor-associated antigen, Other (antigen)
01
Overview
AG-7 antigen is a Lewis A-like glycol-epitope highly expressed in 24–61% of gastric, colorectal, pancreatic, and biliary cancers[5]. It is the target of experimental therapies such as AbGn-107, an antibody-drug conjugate, and is under investigation as both a diagnostic marker and a therapeutic target in gastrointestinal malignancies. Due to ambiguity in its nomenclature, AG-7 antigen can be incorrectly conflated with "I-Ag7", a mouse MHC class II molecule associated with autoimmune diabetes, but in the referenced therapeutic/biomarker research, AG-7 refers specifically to the cancer-associated glycol-epitope[5].
- Other names
- AG7AG-7 antigenLewis A-like antigenI-Ag7 (mouse MHC class II)
02
Mechanism of action
Antibody-drug conjugate binds to AG-7 antigen-expressing cancer cells and delivers cytotoxic payload
03
Biological functions
Immune response mediation (as antigen)Tumor cell recognition
04
Disease associations
Cancer (particularly gastric, colorectal, pancreatic, biliary cancers)
05
Safety considerations
Expression of antigen in normal tissues not fully established (potential for on-target/off-tumor toxicity)
06
Interacting drugs
AbGn-107
07
Biomarkers
AG-7 (Lewis A-like) expression for patient selection in clinical trials
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