Ligand of NUMB protein X 2B, pseudogene (LNX2BP)

Ligand of NUMB protein X 2B, pseudogene (LNX2BP), is a noncoding genomic locus related to the LNX2 gene, which encodes an E3 ubiquitin ligase involved in neurogenesis, cell fate determination, and potential cancer development[2][3]. However, LNX2BP itself is annotated as a **pseudogene** in humans, meaning it does not produce a functional protein and lacks direct biological or therapeutic relevance[1]. The LNX2 family (including LNX1 and LNX2) are important for cellular signaling through interactions with NUMB, impacting NOTCH pathway regulation and various differentiation processes, but these functions are attributed to the protein-coding genes—not their pseudogene relatives[2][3]. If you are specifically interested in therapeutic targets within the LNX protein family, refer to LNX2 (Ligand of NUMB protein X2), the active E3 ligase, involved in ubiquitinating NUMB and regulating neurodevelopmental and oncogenic pathways[2][3][4]. LNX2BP does not describe a relevant actionable or functional protein[1][3].

Other names

Penumbra

None (mechanisms of action only apply to protein-coding targets)