Light Adjustable Lens (LAL) Macromers within Silicone Matrix (LAL)

The Light Adjustable Lens (LAL) macromers within a silicone matrix are the core components of a specialized intraocular lens designed for post-operative refractive adjustment. This system consists of a medical-grade silicone matrix embedded with photo-reactive silicone macromers and a photoinitiator (FDA, 2017). When the lens is exposed to specific patterns of 365 nm ultraviolet (UV) light from a Light Delivery Device, the macromers in the targeted area undergo photopolymerization, creating a chemical concentration gradient (RxSight, 2023). This gradient drives the diffusion of unpolymerized macromers into the irradiated zone, causing a localized change in the lens's thickness and curvature, thereby altering its refractive power (AAO, 2022). This technology is primarily used to treat cataracts and address residual refractive errors such as astigmatism, hyperopia, or myopia after the initial surgery. Unlike traditional intraocular lenses, the LAL allows for non-invasive, precise customization of vision based on the patient's actual post-operative healing and visual needs. The process concludes with a final lock-in treatment that polymerizes all remaining macromers to ensure the long-term stability of the refractive correction.

Other names

RxSight Light Adjustable LensPhotosensitive macromersUV-adjustable intraocular lensLAL

Photopolymerization-induced diffusion where localized UV light triggers macromer polymerization, creating a concentration gradient that causes unpolymerized macromers to migrate and physically alter the lens shape and refractive power.