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Target intelligence / Profile preview
Lipopolysaccharide Antigen (Vibrio) (LPS (Vibrio))
- Target
- LPS (Vibrio)
- Molecular classification
- Lipopolysaccharide, Antigen, Polysaccharide, Cell surface molecule
01
Overview
The lipopolysaccharide (LPS) antigen is a major component of the outer membrane of Gram-negative Vibrio bacteria. It consists of Lipid A, Core polysaccharide, and a variable O-antigen (O-specific polysaccharide). LPS contributes to structural integrity, protects against bile salts and antibiotics, and is a key antigenic determinant for serogroup classification. It elicits strong immune responses and serves as a target for vibriocidal antibodies. The variable O-antigen is the basis for serotyping and is crucial for immune evasion.
- Other names
- Vibrio LipopolysaccharideVibrio LPSO-antigen (Vibrio)Vibrio O-specific polysaccharide
02
Mechanism of action
Target for vibriocidal antibodies, disruption of outer membrane integrity by antimicrobial peptides
03
Biological functions
Structural component of bacterial outer membraneImmune evasionAntigen presentationProtection against antimicrobial peptidesSerotype determination
04
Disease associations
Cholera (Vibrio cholerae)Bacterial infectionImmune response to bacterial infectionTarget for antibody-mediated immunity
05
Safety considerations
Endotoxicity (Lipid A)Potential for triggering excessive inflammatory response
06
Interacting drugs
Polymyxin B
1 more in the full profile.
07
Biomarkers
LPS levels in serum (indicator of infection)Anti-LPS antibody titers (indicator of immunity/exposure)Serogroup-specific LPS for diagnostic identification
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