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Lipoprotein(a) (LPA)
- Target
- LPA
- Molecular classification
- Serine proteinase homolog, Lipoprotein
01
Overview
Lipoprotein(a) [Lp(a)] is a lipoprotein particle consisting of apolipoprotein(a) [apo(a)] covalently bound to apolipoprotein B-100. Apo(a) is encoded by the LPA gene and contains multiple kringle IV type 2 (KIV-2) repeats, leading to size polymorphism. Elevated plasma Lp(a) is an independent risk factor for cardiovascular disease. Therapeutic strategies focus on reducing hepatic LPA mRNA expression.
- Other names
- APOAApolipoprotein(a)
02
Mechanism of action
TALEN-mediated genome editing to reduce LPA mRNA expression in the liver
03
Biological functions
Inhibition of tissue-type plasminogen activator IModulation of fibrinolysisPromotion of thrombogenesis via PAI-1 secretionBinding oxidized phospholipids
04
Disease associations
Cardiovascular diseaseCoronary artery diseaseStrokeAtherogenesis
05
Safety considerations
Potential off-target effects of genome editingImmunogenicity of delivery vehicles
06
Biomarkers
Plasma Lp(a) concentration (mg/dL or nmol/L)
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