Liver qi regulation via multi-herb synergy according to TCM theory; possible modulation of monoamine neurotransmitters based on preclinical data

The target termed "Liver qi regulation via multi-herb synergy (TCM theory); possible modulation of monoamine neurotransmitters" is a conceptual, syndrome-based framework from Traditional Chinese Medicine rather than a discrete molecular target. In TCM, the liver governs the smooth flow of qi and blood, regulates emotions, and influences digestive and reproductive function. Disturbances of liver qi ("liver qi stagnation") are thought to cause various physical and emotional symptoms. TCM approaches this by prescribing herbal formulas, often containing multiple herbs (multi-herb synergy), to "soothe" and "regulate" liver qi. Recent preclinical evidence proposes that some of these formulas might exert their effects by modulating central monoamine neurotransmitters such as serotonin, norepinephrine, and dopamine, which are central to the biological mechanisms of mood and stress regulation in Western medicine. However, this target does not refer to a single, structurally defined molecule or receptor and cannot currently be mapped to a canonical pharmacological entity. In summary, this entry is not a defined molecular target but a broad TCM therapeutic principle possibly linked to modern neurochemical hypotheses.

Other names

Liver qi regulation (TCM context)Liver qi stagnation (TCM pathology)Liver soothing (shu gan, TCM)TCM multi-herb synergy (for liver qi)Harmonization of liver and spleen (TCM syndrome)Modulation of monoamine neurotransmitters (in TCM herbal context)

Enhancement of liver qi flow and alleviation of qi stagnation (TCM pattern); Multi-target action on central neurotransmitters, especially serotonin (5-HT), norepinephrine (NE), dopamine (DA) (preclinical/modern hypothesis about TCM formula effects); Regulation of stress and emotional pathways through presumed effects on CNS monoamines