Long intergenic non-protein coding RNA, regulator of reprogramming (LINC-ROR)

Long intergenic non-protein coding RNA, regulator of reprogramming (LINC-ROR), is a cytoplasmic long non-coding RNA (lncRNA) implicated in the regulation of stem cell pluripotency, reprogramming, and various cancer-related processes[1][2]. Its promoter contains binding sites for stem cell transcription factors SOX2, NANOG, and POU5F1/OCT4, and its expression is upregulated in multiple cancers, where it promotes tumor progression, epithelial-mesenchymal transition, and metastasis, in part by acting as a competing endogenous RNA (ceRNA) that sequesters microRNAs such as miR-145, thereby modulating the activity of key stem cell factors[1][2]. LINC-ROR can suppress p53 translation, modulate chromatin via interactions with histone methyltransferases, and influence signaling pathways like c-Myc, thereby playing diverse roles in tumor biology[1][2]. Elevated LINC-ROR levels are associated with poor prognosis in several cancers, especially as a biomarker in renal cell carcinoma, and it is considered a candidate for non-coding RNA-based cancer prognostics, but is not currently a therapeutic target of any approved drugs[1][2].

Other names

lincRNA-RoRlincRNA-ST8SIA3RORLINC-ROR

Not applicable (no targeted drugs; mechanism relates to suppression/knockdown effects, microRNA sequestration, or pathway modulation)