Long intergenic non-protein coding RNA 265-2, pseudogene (LINC00265-2P)

Long intergenic non-protein coding RNA 265-2, pseudogene (LINC00265-2P) is annotated as a pseudogene of a long intergenic non-coding RNA. Pseudogenes are genomic DNA sequences similar to normal genes but non-functional; they are typically unable to encode functional RNA or protein due to disruptive mutations or lack of regulatory elements. LINC00265-2P is not considered a protein-coding gene or a canonical therapeutic target such as a receptor, enzyme, transporter, or even a characterized non-coding RNA with clear biological function. It is listed under alternative names NCRNA00265-2P and NCRNA00265B[1]. There are functional and disease-relevant findings for the closely related LINC00265, a long intergenic non-coding RNA (not a pseudogene). Studies show that LINC00265 (not LINC00265-2P) can act as an oncogenic lncRNA in cancers like hepatocellular carcinoma and lung adenocarcinoma, promoting cell proliferation and serving as a potential biomarker[2][3][4]. However, no data supports LINC00265-2P itself having such biological or clinical relevance. Summary of notability: - LINC00265-2P is not experimentally supported as a therapeutic target. - Current evidence only supports LINC00265 (functional transcript), not the -2P pseudogene, as functionally relevant in disease[2][3][4]. - This entry is likely an annotation artifact or refers to a non-functional sequence, hence marked as incorrect for a target. If you seek structured data for the functionally relevant transcript, search for LINC00265 without the "-2, pseudogene" suffix.

Other names

NCRNA00265-2PNCRNA00265B