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Long non-coding RNA for association with Brahma (BRM) (lncBRM)
- Target
- lncBRM
- Molecular classification
- Other (long non-coding RNA)
01
Overview
Long non-coding RNA for association with Brahma (BRM) (lncBRM) is a regulatory long non-coding RNA that interacts with the chromatin remodeling ATPase SMARCA2 (also known as BRM), a core catalytic subunit of the SWI/SNF complex[1][3]. In liver cancer stem cells, lncBRM binds to SMARCA2 and inhibits the assembly of SMARCA2 (BAF)-containing SWI/SNF complexes, thereby promoting the formation of SMARCA4 (BRG1)-containing BAF complexes and activating YAP1-driven oncogenic signaling[1][3]. lncBRM is aberrantly overexpressed in liver cancer stem cells and correlates with more aggressive hepatocellular carcinoma phenotypes[3]. It plays a key role in determining cell fate by regulating the epigenetic landscape through chromatin remodeling, acting as a scaffold or decoy in macromolecular complexes[1][3]. There are no known small-molecule drugs that specifically target lncBRM.
- Other names
- LINCR-0003lncBRMlncRNA SMARCA2 associatedLong non-coding RNA for association with Brahma (BRM)LNCBRMCTD-2023N9.2CTD-2023N9.3
02
Mechanism of action
Acts as a molecular scaffold/guide by associating with SMARCA2 to modulate chromatin remodeling complexes, switches the composition from SMARCA2-containing to SMARCA4-containing SWI/SNF complexes, thereby influencing YAP1 (oncogenic pathway) activity
03
Biological functions
Regulation of chromatin remodelingEpigenetic modulationTranscriptional regulationCell fate determinationCancer stem cell maintenance
04
Disease associations
CancerLiver cancer stem cellsHepatocellular carcinoma
05
Biomarkers
Potential role as a marker for liver cancer stem cell phenotype and hepatocellular carcinoma aggressiveness
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