Low silicon rice 1 (Lsi1) (Lsi1)

Low silicon rice 1 (Lsi1) is a member of the Nodulin 26-like intrinsic protein (NIP) subfamily of aquaporins, specifically classified as NIP2-1 in rice (Oryza sativa) (Ma et al., 2006, Nature). It functions as a channel-type transporter located on the distal side of both the exodermis and endodermis cells in rice roots, where it facilitates the passive uptake of silicic acid from the soil solution into the root cells (Ma et al., 2006, Nature; Mitani et al., 2008, Plant and Cell Physiology). Beyond silicon, Lsi1 is also a major pathway for the entry of arsenite, a toxic metalloid, into rice plants, which has significant implications for food safety and human health (Ma et al., 2008, PNAS). Silicon uptake mediated by Lsi1 is crucial for enhancing plant resistance against various biotic and abiotic stresses, including pests, diseases, and heavy metal toxicity (Ma et al., 2006, Nature; Tamai & Ma, 2008, Journal of Plant Nutrition). While not a traditional human therapeutic target, Lsi1 is a primary target for agricultural biotechnology aimed at developing rice varieties with high silicon content and low arsenic accumulation (Ma et al., 2008, PNAS; Zhao et al., 2010, New Phytologist). Understanding its selectivity and regulation is essential for improving crop yield and reducing the dietary intake of arsenic in populations reliant on rice (Mitani et al., 2008, Plant and Cell Physiology; Ma et al., 2008, PNAS).

Other names

OsLsi1Nodulin 26-like intrinsic protein 2-1NIP2-1Silicon transporter 1

Facilitated diffusion of silicic acid and arsenite across the plasma membrane