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Lung Ventilation (Regional Airspace)

Molecular classification: Physiological Process

Overview

Lung ventilation (regional airspace) refers to the distribution of air within different regions of the lung during breathing. It is crucial for understanding normal respiratory physiology and pathologies like ALI, asthma, and COPD. Regional differences are influenced by gravity, posture, lung compliance, and breathing patterns. Measurement techniques include dynamic/static CT, MRI with hyperpolarized gases, and EIT. Understanding regional lung ventilation is essential for diagnosing localized defects, guiding mechanical ventilator settings, and monitoring response to therapies.

Mechanism of action

N/A

Biological functions

Gas ExchangeRespiratory Function

Disease associations

Acute Lung Injury (ALI)ARDSAsthmaChronic Obstructive Pulmonary Disease (COPD)

Safety considerations

OverdistensionAtelectasis FormationAbsorption Atelectasis

Interacting drugs

Bronchodilators

Biomarkers

Percentage Ventilated Volume (%VV)

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