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Lymphocyte antigen 6 complex locus protein G6D (LY6G6D) (LY6G6D)
- Target
- LY6G6D
- Molecular classification
- Ly6/uPAR family [1], GPI-anchored protein [1], Cell surface protein [1]
01
Overview
Lymphocyte antigen 6 complex locus protein G6D (LY6G6D) is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein belonging to the Ly6/uPAR superfamily [1]. It is encoded within the major histocompatibility complex (MHC) class III region on chromosome 6 [3]. While its precise physiological function remains under investigation, it is known to be highly and specifically overexpressed in a significant proportion of colorectal cancers (CRC), particularly in microsatellite stable (MSS) tumors [2]. This restricted expression pattern makes it an attractive candidate for targeted therapies, such as antibody-drug conjugates (ADCs) and T-cell engaging bispecific antibodies [2]. Current research, including the development of agents like SGN-LY6G6D, focuses on leveraging this target to deliver cytotoxic payloads directly to malignant cells while sparing healthy tissue [2]. Its role as a biomarker for patient stratification in CRC clinical trials is also being explored [2].
- Other names
- G6DLY6-G6DNG25Lymphocyte antigen 6 complex locus G6D
02
Mechanism of action
Antibody-drug conjugate-mediated delivery of cytotoxic monomethyl auristatin E (MMAE) [2]
03
Biological functions
Cell adhesion [1]Signal transduction [1]Immune response modulation [3]
04
Disease associations
Colorectal cancer [2]Cancer [2]
05
Safety considerations
Potential for on-target, off-tumor toxicity in normal tissues with low-level expression [2]General antibody-drug conjugate (ADC) related toxicities [2]
06
Interacting drugs
SGN-LY6G6D (PF-08046052) [2]
07
Biomarkers
LY6G6D protein expression by immunohistochemistry [2]LY6G6D mRNA expression [2]
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