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Lyn proto-oncogene, Src family tyrosine kinase (None)
- Target
- None
- Molecular classification
- Enzyme, Protein tyrosine kinase, Src family kinase
01
Overview
LYN encodes a member of the Src family of protein tyrosine kinases. It is primarily expressed in hematopoietic cells and plays a central role in regulating cell activation and signaling thresholds, especially within immune cells such as B lymphocytes. LYN exists as two main isoforms, LynA and LynB, due to alternative splicing. It is a potential therapeutic target for aggressive cancers and is also implicated in autoimmune diseases.
- Other names
- LYNTyrosine-protein kinase Lyn
02
Mechanism of action
Kinase inhibition; Allosteric activation
03
Biological functions
Signal transductionRegulation of immune responsesCell proliferationCalcium mobilizationDifferentiationImmune regulation
04
Disease associations
AutoimmunityBreast cancerCancerMetastasis
05
Interacting drugs
Dasatinib
1 more in the full profile.
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