Lysine-specific demethylase 4B (KDM4B) mRNA (KDM4B mRNA)

Lysine-specific demethylase 4B (KDM4B) mRNA is the messenger RNA transcript that encodes the KDM4B enzyme, a key epigenetic regulator belonging to the Jumonji C (JmjC) domain-containing family (UniProt: O94953). The encoded protein specifically catalyzes the demethylation of tri- and di-methylated histone H3 at lysine 9 (H3K9me3/me2) and lysine 36 (H3K36me3/me2), thereby modulating chromatin structure and gene expression (NCBI Gene ID: 23030). KDM4B is frequently upregulated in various malignancies, including breast, prostate, and colorectal cancers, where it promotes cell proliferation, survival, and the response to hypoxic stress (Berry & Janknecht, 2013, PMID: 23511301). Targeting the KDM4B mRNA using RNA interference (RNAi) or antisense oligonucleotides (ASOs) offers a method to silence the expression of this oncogenic driver at the pre-translational level (Yang et al., 2015, PMID: 25613340). While small molecule inhibitors typically target the protein's catalytic site, mRNA-targeted strategies provide an alternative approach to reduce the overall abundance of the KDM4B protein. Current therapeutic development focuses on improving the stability and delivery of these RNA-based agents to ensure effective and specific gene silencing in target tissues (Guerra-Calderas et al., 2015, PMID: 25914314).

Other names

JMJD2B mRNAJumonji domain-containing protein 2B mRNAKDM4B transcript

Targeted degradation of mRNA via RNA interference (RNAi) or RNase H-mediated cleavage, resulting in the depletion of KDM4B protein levels.