Lysosomal membrane (in antigen-presenting cell) (null)

The **lysosomal membrane in antigen-presenting cells (APCs)** is the lipid bilayer that surrounds the lysosome, a key organelle responsible for the degradation and processing of exogenous antigens. This membrane contains integral membrane proteins such as LAMP1, LAMP2, LIMP2, and SNAREs, which together regulate: - protection from self-degradation by lysosomal enzymes - acidification of the lumen for hydrolase activity via V-ATPase - vesicle trafficking, fusion, and antigen presentation pathways In APCs, lysosomes are dynamically involved in the processing of internalized antigens into peptides, which are loaded onto MHC class II molecules for subsequent presentation to T cells, a critical step in adaptive immunity. The lysosomal membrane machinery also supports fusion with phagosomes/endosomes and recycling of biomolecules. Lysosomal dysfunction or loss of membrane integrity disrupts antigen processing, immune responses, and can promote autoimmunity, neurodegeneration, or lysosomal storage diseases.

Other names

Lysosomal membraneslysosomal limiting membranelysosome membrane in APCsLAMP-positive vesicle membranes

Not applicable for the membrane structure; drugs may disrupt lysosomal acidification or membrane fusion indirectly